Date of Birth: 06/30/1926
Place of birth: Brooklyn
Citizenship: United States
The synthesis of the first p-DNA
Paul Berg, the son of a housewife Sarah Brodsky (Sarah Brodsky) and clothing producer Harry Berg (Harry Berg), born on June 30 1926. Paul Young became interested in biology, after reading a few struck his books, including `Hunters mikrobami` (` Microbe Hunters`) Paul de Kruif (Paul de Kruif). He graduated from the School Abraham Lincoln High School in 1936, received a bachelor`s degree in biochemistry from the University of Pennsylvania (Penn State University) in 1948 and Doctor of Science (Biochemistry) at Case Western Reserve University (Case Western Reserve University) in 1952 th.
After finishing graduate school Berg from 1952 to 1954-th was a researcher (with a degree) in the American Cancer Society (American Cancer Society), worked at the Institute cytophysiology in Copenhagen, Denmark (Institute of Cytophysiology, Copenhagen, Denmark), and biomedical WUSM research facility in St. Louis, Missouri (St. Louis, Missouri). In 1954, Paul studied cancer at the Department of Microbiology at WUSM, where he worked with Arthur Kornberg (Arthur Kornberg). In the same institution, in the period from 1955 th and 1959 th, Berg was a professor, after which he moved to Stanford University, where he taught biochemistry to 2,000 th. He was the director of the center Bekmenskogo molecular and genetic medicine (BCMGM) from 1985 to 2000-th.
While studying in graduate school, Berg worked with radioisotope modifiers to study the intermediate metabolism. His research has led to the understanding of how foods prevraschayutsyav porous materials using isotopic carbons or heavy nitrogen atoms. Doctoral thesis Paul was devoted to what is known today as the conversion of formic acid, formaldehyde and methanol in a fully restored methyl group of methionine. Berg was also one of the first who demonstrated as folic acid and vitamin B12 are involved in the synthesis of methionine amino animal.
Probably the best known American biochemist bought for his pioneering work involving recombinant DNA (bDNA). Berg and his colleagues synthesized DNA first district in 1972. Later, in 1980-2000 gg., He studied the mechanism of recovery of recombinant DNA unstructured. In 1985, Paul helped open interdisciplinary Tsentrmolekulyarnoy and Genetic Medicine at Stanford University. Together with the staff of the Biotechnology Research Institute DNAX he is seriously interested in the synthesis of immunoglobulins based on p-DNA, and then switched to interleukins, armed with their cloning systems.
Berg was the organizer Asilomarskoy by recombinant DNA conference in 1975, the results of which are described in the same year in the scientific work. This conference made it possible to truly appreciate the possible hazards and the level of control over the research of recombinant DNA and to determine the principles of biotechnology research.
One of the last and most important of his publications, which Berg speculates on the origin and emergence of recombinant DNA technology, came out in 2010.