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Otto Heinrich Warburg

Picture of Otto Heinrich Warburg

Date of Birth: 08/10/1883

Age: 86

Place of birth: Freiburg

Citizenship: Germany

Background

Otto Heinrich Warburg (Warburg, Otto Heinrich) (1883-1970), a German biochemist and physiologist, awarded in 1931 the Nobel Prize in Physiology or Medicine Prize for his discovery of the nature and action of the respiratory enzyme mechanism. Born October 8, 1883 in Freiburg. In 1906, the University of Berlin received his Ph.D. in chemistry, and in 1911 the University of Heidelberg - the degree of Doctor of Medicine. Until 1913 he worked at the Kaiser Wilhelm Society, from 1915 - professor of physiology at the University of Berlin. In 1931 he headed the Institute of Cell Physiology in Berlin.

Research Warburg devoted to the processes of cellular respiration, enzymes, redox reactions in living cells. Already in 1912, Warburg suggested the existence of respiratory enzymes that activate oxygen. He showed that cells utilize oxygen with the help of iron-containing proteins - hemoprotein and in 1924 announced the discovery of cytochrome c oxidase - an enzyme that plays a key role in this process. In 1932, together with U.Hristianom first received new respiratory enzyme yellow, called flavin. It turned out that it is representative of a large group of flavoproteins - oxidative enzymes, which form together with tsitohrohromami respiratory chain. Three years later, it was allocated one more important connection - nicotinamide, which is part of the enzymes that are involved in the transfer of hydrogen (dehydrogenases).

Among other works Warburg - definition of the structure of enzymes, the study of fermentation, glycolysis in tumor tissues, photosynthesis. Scientist designed apparatus for studying the processes of tissue respiration, fermentation, enzymatic reactions (Warburg apparatus). Warburg died in (West) Berlin, August 1, 1970.