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Hara Gobind Khorana

Picture of Hara Gobind Khorana

Date of Birth: 09/01/1922

Age: 94

Birth Place: Raipur

Citizenship: United States

Background

Primary education received K. in extracurricular class, which was engaged in a village teacher. Then he graduated from high school in Multan (Punjab), and then studied chemistry at the Punjab University in Lahore. In 1943 he received the University bachelor of science degree with honors, and two years later - a Master of Science degree with honors.

In 1945, Karl received a state scholarship and went to study organic chemistry at the University of Liverpool. In 1948, for his thesis on chemical pigments violatseinu stained some bacterial cells, he received his doctorate in organic chemistry, and then spent a year studying the chemical structure of some alkaloids (organic bases) together with Vladimir Prelog in the Zurich Federal Institute of Technology in Switzerland . At the end of 1949 K. was appointed researcher at the University of Cambridge. Here, working together with Alexander Todd, he became interested in the biochemistry of nucleic acids - high molecular weight organic compounds contained in the nuclei of cells.

In 1952, K. became director of the Department of Organic Chemistry, British Columbia Research Council at the University of British Columbia in Vancouver (Canada). There he studied the chemical structure atsetilkoenzima A. Enzymes, or enzymes - is a biologically active substance of protein nature that accelerate biochemical reactions in cells, and co-enzymes (coenzymes) - This connection is usually included in the enzymes and provide their activity. Acetyl coenzyme A, Fritz Lipman opened in 1945, it is a coenzyme A condensation product of acetic acid and plays a key role in the metabolism of carbohydrates, fats and proteins in the cells. In 1949, Karl and his colleague John Moffat synthesized acetyl coenzyme A. Because the method developed by them was much easier and cheaper than previously existing methods for isolating the substance from yeast, it gave the opportunity to receive acetyl coenzyme A in the amounts necessary for the study of cellular processes as the breakdown of carbohydrates to release energy. This work brought K. worldwide recognition.

In 1960, K. was appointed one of the directors of the Institute of Studies of enzymes University of Wisconsin-Madison. The following year he published "The value of the latest advances in the chemistry of phosphoric acid esters for biological processes