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Gerkhard Domagk

Picture of Gerkhard Domagk

Date of Birth: 10/30/1895

Age: 68

Place of birth: Leygau

Citizenship: Germany

Background

German bacteriologist Gerhard Johannes Paul Domagk was born in the family of Paul Domagk and Martha (Reimer) Domagk in Leygau, Brandenburg suburb. He received his primary education in Sommerfeld, where his father worked as a teacher and assistant principal. After graduating from high school in Legnica Domagk in 1914, before the First World War, he began training at the Medical Faculty of the University of Kiel. He volunteered for the Eastern Front, was wounded and after recovery he served in the medical units until the end of the war. He then continued his studies in Kiel and in 1921 received a medical degree with a thesis on the formation of creatinine in the body after exercise.

Left in the University of Kiel, Domagk worked as an assistant in the department of chemistry and pathology, at the same time explore the use of X-rays in nephritis and cancer pathology at the Institute of Greifswald, where in 1924 became assistant professor (Visiting Professor) in general pathology and anatomy. The following year, Domagk was appointed assistant professor at the University of Munster, and in 1928 - Professor of General Pathology and Pathological Anatomy. In Greifswald and Muenster he began cancer problems.

In 1927, the German chemical concern "IG Farben "invited Domagk, who turned 32 years old, to the post of Director of Experimental Research Laboratory of Pathology and Bacteriology in Wuppertal-Elberfeld. He remained in this place until his retirement.

Opening in 1910, pharmacologist and immunologist Paul Ehrlich organic matter salvarsan for syphilis gave impetus to research other chemical products for the treatment of infectious diseases. Although there had been some progress in the use of chemotherapy for the treatment of tropical diseases and diseases caused by protozoa, but Domagk tested the alleged antibacterial drugs for bacterial infections, such as pneumonia and tuberculosis.

Domagk began a systematic search for the possible use of new dye in medical practice. Substances first tested for their effect on some types of microbes. Then determined tolerance dose in laboratory animals, and finally examined for their efficiency of infection in animals and humans. In 1932, Domagk found that a red azo dye synthesized by chemists Fritz and Joseph Mitchum Klarerom and implemented concern "IG Farben "entitled" prontosil "as a dye for dyeing leather fast, in combination with a sulfonamide radical is effective against streptococcal infections in mice.

Experimental results Prontosil use as a therapeutic drug for the first time were published in February 1935, is now become a classic article "German medical weekly